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Description
In recent years many developments, such as the use of levo dopa in Parkinsonism, the manipulation of excitation in epilepsy and the discovery of endogenous opioids, have brought basic neuropharmacology and the successful treatment of disorders of the C.N.S. much closer together. It is likely that future prospects for drug therapy in neurology and psychiatry will depend very much on a better understanding of neurotransmitter function and manipulation.听
This neuropharmacology module tries to provide a basis for such an understanding. The evidence for different transmitters (from morphological, electrophysiological, pharmacological and biochemical studies) is evaluated so as to build up a picture of their pre- and post-synaptic actions and their interactions in specific pathways and brain areas. This knowledge is then applied to a consideration of various disease states and drug action. Special emphasis is given to neurotransmitter function and malfunction in epilepsy, Parkinsonism, memory, cell death and pain states and to the mode of action of drugs in these conditions.听
Students will attend a comprehensive series of lectures on these issues given by experts in the field.听
Indicative Lecture Topics (based on 2023/2024 syllabus)听
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Fundamentals of Neuropharmacology听
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Transmitter systems and their modulation听
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Transmitter release mechanisms听
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Neuropharmacological techniques听
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Glutamate receptors and fast transmission听
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Glutamate Receptors and disease听
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Metabolic glutamate receptors听
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Neuropharmacology of memory听
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Atypical transmitters听
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GABA-A Inhibition and epilepsy听
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GABA-B and disease听
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Cholinergic Transmission 鈥� Nicotinic aspects听
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Cholinergic transmission: Muscarinic aspects听
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惭辞苍辞补尘颈苍别蝉听
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Calcium channels and disease听
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Alzheimer's disease听
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Parkinson's disease听
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Pain and analgesics听
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 8th April 2024.
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